Hydrophilic Degradable Microspheres for Delivering Buprenorphine
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United States of America Patent
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Issued Date -
Aug 3, 2023
app pub date -
Jul 7, 2021
filing date -
Jul 7, 2020
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Abstract
The invention relates to a composition comprising an effective amount of buprenorphine or a pharmaceutically acceptable salt thereof, at least one hydrophilic degradable microsphere comprising a crosslinked matrix, and a pharmaceutically acceptable carrier for administration by injection, the crosslinked matrix being based on at least a) between 10% and 90% of hydrophilic monomer of general formula (I); b) between 0.1 and 30% mol of a cyclic monomer of formula (II); and c) between 5% and 90% of one degradable block copolymer cross-linker, wherein the degradable block copolymer cross linker is linear or star-shaped and presents (CH2═(CR11))-groups at all its extremities and wherein the degradable block copolymer crosslinker has a partition coefficient P of between −3 and 11.20. The invention also relates to such a composition for use for preventing and/or treating moderate to severe pain, post-surgical pain and/or opioid use disorders.
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