Hydrophilic Degradable Microsphere for Delivering Travoprost
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United States of America Patent
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Issued Date -
Aug 3, 2023
app pub date -
Jul 7, 2021
filing date -
Jul 7, 2020
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Abstract
The invention relates to a composition comprising an effective amount of a prostaglandin analogue, at least one hydrophilic degradable microsphere comprising a crosslinked matrix, and a pharmaceutically acceptable carrier for administration by injection, the crosslinked matrix being based on at least a) between 10 mol % and 90 mol % of hydrophilic monomer of general formula (I); b) between 0.1 and 30 mol % of a cyclic monomer of formula (II); and c) between 5% and 90% of one degradable block copolymer cross-linker, wherein the degradable block copolymer crosslinker is linear or star-shaped and presents (CH2═(CR11))-groups at all its extremities. The invention also relates to such a composition for use for preventing and/or treating moderate to ocular hypertension or glaucoma.
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