METHODS FOR PURIFICATION OF ARYLSULFATASE A

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United States of America Patent

APP PUB NO 20230235303A1
SERIAL NO

17810396

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Abstract

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The present invention provides, among other things, improved methods for purifying arylsulfatase A (ASA) protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant ASA protein can be purified from unprocessed biological materials, such as, ASA-containing cell culture medium, using a process involving as few as four chromatography columns and only one step of post-chromatographic ultrafiltration/diafiltration.

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Patent Owner(s)

Patent OwnerAddress
TAKEDA PHARMACEUTICAL COMPANY LIMITED1-1 DOSHOMACHI 4-CHOME CHUO-KU OSAKA-SHI OSAKA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheang, Bee Lin Lexington, US 3 1
Jang, Mei Huei Lexington, US 3 1
Nichols, Dave Lexington, US 17 36
Quinones-Garcia, Igor Lexington, US 13 123

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