T CELL, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF
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United States of America Patent
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Jul 13, 2023
app pub date -
May 15, 2020
filing date -
May 15, 2020
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Abstract
Provided are a T cell deleting the Ryr2 gene and a preparation method. Also provided are an Ryr2 antagonist, an Ryr2 overexpressing T cell, a method and applications for regulating Ryr2 expression, regulating basal Ca2+ oscillation, regulating m-Calpain activity, and increasing bonding strength between T cells and DC cells, applications of a reagent implementing the functions in preparing a medicament for treating an infectious disease, inflammation, or tumor, and a method for transforming Tconv cells into being functionally similar to Treg cells.
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