METHOD FOR SELECTION AND PRODUCTION OF TAILOR-MADE HIGHLY SELECTIVE AND MULTI-SPECIFIC TARGETING ENTITIES CONTAINING AT LEAST TWO DIFFERENT BINDING ENTITIES AND USES THEREOF
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United States of America Patent
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Issued Date -
Jul 13, 2023
app pub date -
Jun 28, 2022
filing date -
Jun 27, 2012
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Abstract
Herein is reported a method for producing a bispecific antibody comprising the step of incubating
- (i) an antibody Fab fragment or a scFv antibody comprising within the 20 C-terminal amino acid residues the amino acid sequence LPX1TG (SEQ ID NO: 01),(ii) a one-armed antibody comprising a full length antibody heavy chain, a full length antibody light chain, and an Fc-heavy chain, whereby the full length antibody heavy chain and the full length antibody light chain are cognate antibody chains that thereof forms an antigen binding site,whereby the full length antibody heavy chain and the Fc-heavy chain are covalently linked to each other via one or more disulfide bonds forming an antibody hinge region, andwhereby the Fc-heavy chain has an oligoglycine amino acid sequence at its N-terminus,and (iii) a Sortase A enzyme.
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