RIBOSWITCH MODULES AND METHODS FOR CONTROLLING EUKARYOTIC PROTEIN TRANSLATION
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United States of America Patent
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Jul 6, 2023
app pub date -
Jun 11, 2021
filing date -
Jun 12, 2020
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Abstract
The present disclosure provides genetic constructs comprising a recombinant internal ribosome entry site (IRES), which may be used as riboswitches to modulate translation of an operably-mRNA sequence encoding a protein of interest. In other aspects, the disclosure provides recombinant cells, methods, kits and systems that utilize the same, e.g., to provide a platform for modulating the expression of essentially any protein of interest in a eukaryotic cell.
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