ADAPTIVE RECOMBINANT NANOWORMS FROM GENETICALLY ENCODABLE STAR AMPHIPHILES
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Jun 22, 2023
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Nov 8, 2022
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Nov 8, 2021
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A programmable assembly of proteins into well-defined nanoworms with broadened stability regimes is disclosed. Posttranslational modifications (PTMs) were used to generate lipidated proteins with precise topological and compositional asymmetry. Using an integrated experimental and computational approach, the material properties (thermoresponse and nanoscale assembly) of these hybrid amphiphiles are modulated by their amphiphilic architecture. The judicious choice of amphiphilic architecture can be used to program the assembly of proteins into adaptive nanoworms that undergo a morphological transition (sphere-to-nanoworms) in response to temperature stimuli.
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