METHODS OF TREATMENT AND RELATED COMPOSITIONS

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20230183297A1
SERIAL NO

18048745

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to methods of treating a disease characterised by aberrant cell proliferation (e.g., a cancer) in a human subject in need thereof. In particular, the present invention relates to treating the above conditions by administering a therapeutically effective amount of at least one agent that increases activation of a receptor of at least one type II interferon and/or type I interferon, and administering to the subject at least one agent that inhibits the Hedgehog (Hh) signalling pathway (e.g., Vismodegib). Also provided are pharmaceutical compositions, including controlled release pharmaceutical compositions, containing at least one agent that increases activation of a receptor of at least one type II interferon and/or type I interferon (e.g., a checkpoint inhibitor), an inhibitor of Hh signalling pathway, and a controlled release matrix such as a SiO2 matrix gel.

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Patent Owner(s)

Patent OwnerAddress
ASCEND BIOPHARMACEUTICALS LTDVITORIA AUSTRALIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Leong, Clement South Melbourne, AU 8 18
Pietersz, Geoffrey South Melbourne, AU 4 1

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