PATTERNING-MEDIATED SUPRAMOLECULAR ASSEMBLY OF LIPIDS INTO NANOSTRUCTURES
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United States of America Patent
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Issued Date -
Jun 15, 2023
app pub date -
Dec 15, 2022
filing date -
Dec 15, 2021
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Abstract
Methods of making a supramolecular structure of lipids. The methods include providing an ink made of an aqueous solution of lipid micelles that are deposited onto a polymer pen or an array of polymer pens, such as by an electrospray technique to achieve a homogenous coverage of single and isolated micelles. The method further comprises transferring the ink to a substrate using polymer pen lithography (PPL). Nanoconfinement of the lipid micelles associated with the disclosed method, allow the lipid micelles to rearrange and ultimately lead to a highly ordered and homogenous supramolecular lipid structure. A supramolecular assembly made using the disclosed method and nanoscale delivery system comprising the supramolecular assembly of lipids are further disclosed.
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