PD-L1 BINDING PEPTIDES
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United States of America Patent
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Issued Date -
Jun 8, 2023
app pub date -
Apr 29, 2021
filing date -
Apr 29, 2020
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Abstract
The disclosure provides synthetic peptides that selectively bind to the PD-L1 protein on the surface of cells expressing PD-L1. The PD-L1 binding peptide may comprises the amino acid sequence MX1X2X3X4DHX5LNKFX6IX7HX8X9X10X11X12X13 (SEQ ID NO: 177) or MXIFπXXIXXXΩWXLXXA (SEQ ID NO: 1). Peptides of the disclosure may be functionalized using one or more diagnostic agents to aid in various detection modalities or with a cytotoxic agent to treat various disease states such as cancer. Also provided are compositions that include the PD-L1 binding peptides or functionalized PD-L1 binding peptides.
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