FORMULATION CONTAINING HMGB1 PARTIAL PEPTIDE
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United States of America Patent
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Issued Date -
Jun 8, 2023
app pub date -
Apr 19, 2021
filing date -
Apr 20, 2020
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Abstract
A pharmaceutical composition containing the substance according to any one of the following (a) to (c), an organic acid, a metal salt of an organic acid, and a sugar and/or a sugar alcohol, wherein when the pharmaceutical composition is dissolved in distilled water for injection, a pH of the pharmaceutical composition is 3.0 to 4.5, the substance according to any one of the following (a) to (c) can be stabilized;
- (a) an HMGB1 fragment peptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or an acid addition salt thereof;(b) a peptide comprising an amino acid sequence having substitution, deletion, insertion or addition of one or more amino acids in the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof; and(c) a peptide comprising an amino acid sequence having about 80% or more of sequence identity to the amino acid sequence set forth in SEQ ID NO: 1, and having an activity of stimulating migration of a cell, or an acid addition salt thereof.
First Claim
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| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| EP | A1 | EP4147711 | Apr 19, 2021 |
| JP | A1 | JPWO2021215375 | Apr 19, 2021 |
| WO | A1 | WO2021215375 | Apr 19, 2021 |
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