DRUG-LOADED MICROBEAD COMPOSITIONS, EMBOLIZATION COMPOSITIONS AND ASSOCIATED METHODS
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United States of America Patent
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Issued Date -
Jun 8, 2023
app pub date -
Feb 7, 2023
filing date -
Dec 18, 2017
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Abstract
Methods for preparing a drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. The drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. The therapeutic agent is not chemically bonded to the water-swellable polymer material. The drug-loaded microbead composition has a water content of less than 1% by weight, based on the total weight of the drug-loaded microbead composition. The drug-loaded microbead composition may be rehydrated to form an embolization composition for use in in embolization therapy.
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