METHOD FOR PRODUCING ALBICANOL AND/OR DRIMENOL

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United States of America

APP PUB NO 20220186265A1
SERIAL NO

17673465

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Abstract

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Described herein is a method of producing a drimane sesquiterpene such as albicanol, drimenol and/or derivatives thereof by contacting at least one polypeptide with farnesyl diphosphate (FPP) with a polypeptide including a Haloacid dehalogenase (HAD)-like hydrolase domain and having bifunctional terpene synthase activity. The method may be performed in vitro or in vivo. Also described herein are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. The described method further provides host cells or organisms genetically modified to express the polypeptides and useful to produce a drimane sesquiterpene such as albicanol, drimenol and/or derivatives thereof.

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  • 2022 Application Filing Year
  • C12P Class
  • 1198 Applications Filed
  • 236 Patents Issued To-Date
  • 19.70 % Issued To-Date
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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anziani, Pauline Satigny, CH 3 1
Goerner, Christian Satigny, CH 2 1
Schalk, Michel Satigny, CH 42 162
Solis, Escalante Daniel Satigny, CH 7 1

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges3301397601 - 1011 - 20020040060080010001200140016001800200022002400260028003000320034003600

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