PLASMID ADDICTION SYSTEM TO DRIVE DESIRED GENE EXPRESSION
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United States of America Patent
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May 11, 2023
app pub date -
Jul 1, 2022
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Jul 21, 2017
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Abstract
The present invention relates to a Plasmid Addiction System for the stabilization of expression plasmids encoding proteins of interest. The invention uses a succinate cycle optimization to ensure the expression of plasmid(s) of interest. By ensuring that plasmids of interest contain genes necessary in the succinate cycle, the system ensures that the passage of the plasmid to daughters and therefore improves the efficiency of production and expression of genes and/or products of interest.
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