Coumarin Derivatives of Sugar Analogs and Uses Thereof
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United States of America Patent
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May 4, 2023
app pub date -
Sep 13, 2022
filing date -
Sep 13, 2021
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Provided herein are coumarin derivatives of sugar analogs which are used to measure the rate of hydrolysis of these sugar analogs when contacted with a glycosidase. The reactivity of the coumarin derivatives serves as a convenient method for estimating for the rate of hydrolysis of sugar analogs when used a promoiety with cytotoxic drugs to generate senolytic agents with improved selectivity for killing senescent cells.
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