BEAD INCUBATION AND WASHING ON A DROPLET ACTUATOR
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United States of America Patent
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Issued Date -
Apr 27, 2023
app pub date -
Dec 9, 2022
filing date -
Apr 18, 2006
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Abstract
Methods are provided for separating magnetically responsive beads from a droplet in a droplet actuator. Droplet operations electrodes and a magnet are arranged in a droplet actuator to manipulate a bead-containing droplet and position it relative to a magnetic field region that attracts the magnetically responsive beads. The droplet operations electrodes are operated to control the droplet shape and transport it away from the magnetic field region to form a concentration of beads in the droplet. The continued transport of the droplet away from the magnetic field causes the concentration of beads to break away from the droplet to yield a small, concentrated bead-containing droplet immobilized by the magnet.
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