STABLE REACTIVE COMPOSITIONS FOR BIOCONJUGATION, PROBES, AND PROTEIN LABELING

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United States of America Patent

APP PUB NO 20230111712A1
SERIAL NO

17905787

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Modular Meldrum's acid amine-reactive Michael acceptor (MaMa)—based molecules that are stable probes for high pH environents and bioconjugations. The molecules of the present invention can selectively label and protect lysine residues. In certain embodiments, the molecules can selectively react with lysine at particular pH levels. The probes of the present invention may be used to label proteins in a fluorescent manner, for purification, imaging, or general protein modifications, however the present invention is not limited to the aforementioned applications.

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Patent Owner(s)

Patent OwnerAddress
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONATHE UNIVERSITY OF ARIZONA TECH LAUNCH ARIZONA 1600 E IDEA LANE SUITE 110 TUCSON AS 85713

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davis, Garrett Tucson, US 1 0
Jewett, John C Tucson, US 17 88
Sofka, Holly Tucson, US 1 0

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