POLYPEPTIDE VARIANTS AND USES THEREOF
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United States of America Patent
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Issued Date -
Apr 6, 2023
app pub date -
May 16, 2022
filing date -
Nov 1, 2016
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Abstract
Described herein are polypeptides and antibodies comprising a variant Fc region. The variant Fc region provides for stabilized Fc-Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, while at the same time also having decreased complement-dependent cytotoxicity (CDC) and may also have decreased activation of other effector functions resulting from one or more amino acid modifications in the Fc region.
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