REAGENT COMBINATION AND KIT FOR DETECTING LIVER CANCERS, AND USE THEREOF
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United States of America Patent
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Issued Date -
Mar 30, 2023
app pub date -
Sep 26, 2022
filing date -
Sep 26, 2022
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Abstract
Provided is a reagent combination for detecting a liver cancer. The reagent combination includes any one of the following detection reagents: 1) a detection reagent for detecting methylation level of at least one of the following methylation sites of the PAK1 gene: cg17202086, cg26996201, and cg18309286; 2) a detection reagent for detecting methylation level of at least one of the following methylation sites of the OTX1 gene: cg23229261 and cg10122865; and 3) a detection reagent for detecting methylation level of methylation site cg16657538 of the ZNF397OS gene. Further provided are use of the reagent combination, and a kit including the reagent combination. By using the reagent combination of the present invention, a liver cancer may be detected clinically in a tissue sample with fewer markers, and may be detected sensitively and specifically by detecting methylation sites, and the cost and time are saved.
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