C10-Alkylene Substituted 13-Membered Macrolides and Uses Thereof
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United States of America Patent
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Mar 23, 2023
app pub date -
Nov 18, 2019
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Nov 19, 2018
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Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides. Formula (I)
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