MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
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United States of America Patent
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Issued Date -
Mar 16, 2023
app pub date -
May 19, 2020
filing date -
May 20, 2019
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Abstract
Anti-CD74 antibody-drug conjugates are disclosed. The anti-CD74 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD74 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.
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