Substituted quinoline analogs as aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors

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United States of America Patent

PATENT NO 11795177
APP PUB NO 20230079399A1
SERIAL NO

17682654

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Abstract

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The disclosure provides compounds of Formula I, which may be useful as aldehyde dehydrogenase inhibitors and the pharmaceutically acceptable salts thereof. The variables, J, R4, G, Q, and ring A are defined herein. Aldehyde dehydrogenase inhibitors of Formula I are useful for treating a variety of conditions including cancer and inflammation. The disclosure includes methods for using compounds and salts of Formula I to treat colon cancer, pancreatic cancer, nasopharyngeal carcinoma, thyroid cancer, prostate cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, hepatocellular carcinoma, leukemia, brain tumors breast cancer, atherosclerosis, ischaemic heart disease, acne vulgaris, asthma, autoimmune diseases, autoinflammatory diseases, chronic prostatitis, glomerulonephritis, inflammatory bowel disease, pelvic inflammatory disease, reperfusion injury, rheumatoid arthritis, sarcoidosis, transplant rejection, vasculitis, and interstitial cystitis. The disclosure also includes pharmaceutical compositions containing a compound or salt of Formula I.

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THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESOFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH 6011 EXECUTIVE BOULEVARD SUITE 325 MSC 7660 BETHESDA MARYLAND 20892-7660 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Maloney, David J Points of Rocks, US 34 503
Martinez, Natalia Rockville, US 3 1
Simeonov, Anton Bethesda, US 33 141
Yang, Shyh Ming Doylestown, US 12 15
Yasgar, Adam Washington, US 6 6

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