TOLL-LIKE RECEPTOR AGONIST FORMULATIONS AND METHODS OF USE
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United States of America Patent
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Issued Date -
Mar 9, 2023
app pub date -
Jan 13, 2021
filing date -
Jan 13, 2020
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Abstract
Aspects of the disclosure relate to nanoparticle formulations and methods for generating nanoparticles. Embodiments include nanoparticles comprising an amphiphile and a polymer co-assembly agent. In some cases, polymers for use in therapeutic delivery are described. In some embodiments, the disclosed methods and compositions involve TLR agonists and formulations thereof capable of activating an immune response. Certain aspects relate to nanoparticles comprising linked TLR agonists for use in immunotherapy.
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