METHODS OF TREATING TUMORS
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United States of America Patent
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Issued Date -
Mar 2, 2023
app pub date -
Jan 8, 2021
filing date -
Jan 10, 2020
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Abstract
The present disclosure provides methods of treating a tumor (e.g., renal cell cancer) by administering an immunotherapy comprising dendritic cells loaded with RNA encoding a tumor antigen and a pharmaceutical which can decrease circulating IgG levels, block IgG-mediated activation of CD16+ T cells, decrease the concentration and/or function of B cells, reduce the frequency of CD38+ TGF-β+ B cells, decrease B cell secretion of TGF-β, and/or sustain the frequency of CD25+CD28+ CD4 and/or CD8 T cells.
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