METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION
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United States of America Patent
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Feb 16, 2023
app pub date -
Jun 15, 2021
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Jun 15, 2021
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Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
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