Rapid diagnostic test for lamp

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United States of America Patent

PATENT NO 11732315
APP PUB NO 20230048863A1
SERIAL NO

17936084

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Abstract

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Compositions and methods are described that are directed to specific and sensitive methods of target nucleic acid detection and more specifically detecting target nucleic acids directly from biological samples. The compositions and methods were developed to be easy to use involving a minimum number of steps and giving rapid and consistent results either at point of care or in high throughput situations. The compositions and methods are directed to labelled probes and their uses in Loop-Mediated Isothermal Amplification (LAMP) diagnostic tests to detect target DNA from the environment or from an individual and also to detect specific variants of the target DNA, both with similar sensitivity. The compositions and methods may use any single improvement or combination of improvements selected from thermolabile enzyme variants, poloxamers, various salts, indicators and one or more LAMP primer sets for detecting single and/or multiple targets, probes for detecting variants of the targets including SARS-CoV-2 variants and lateral flow devices.

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Patent Owner(s)

  • NEW ENGLAND BIOLABS, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barry, Andrew Ipswich, US 12 58
Carlow, Clotilde Ipswich, US 7 5
Correa,, Jr Ivan R Hamilton, US 18 169
Evans,, Jr Thomas C Topsfield, US 34 215
Hunt, Eric Danvers, US 35 228
Li, Zhiru Lexington, US 10 16
Nichols, Nicole Reading, US 17 78
Patton, Gregory Peabody, US 10 20
Poole, Catherine B Medford, US 4 1
Ren, Guoping Danvers, US 11 16
Slayton, Esta Epping, US 7 1
Strimpel, Harriet M Manchester, US 4 1
Tanner, Nathan West Newbury, US 34 288
Zhang, Yinhua North Reading, US 23 218

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