Ribosome-Mediated Incorporation of Peptides and Peptidomimetics
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United States of America Patent
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Feb 16, 2023
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Jul 19, 2022
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Jul 19, 2022
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Abstract
Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
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