METHODS TO SPECIFICALLY PROFILE PROTEASE ACTIVITY AT LYMPH NODES
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United States of America Patent
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Issued Date -
Feb 9, 2023
app pub date -
Aug 2, 2022
filing date -
Aug 2, 2022
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Abstract
In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of proteases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions (e.g., metastatic cancer, infection with certain pathogenic agents).
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