BIODEGRADABLE POLYMERIC COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF
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United States of America Patent
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Jan 5, 2023
app pub date -
Dec 3, 2020
filing date -
Dec 3, 2020
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Abstract
Disclosed herein compositions of polysaccharides chemically cross-linked by aromatic dialdehydes. The compositions may be in form of polymeric sheets for a variety of applications. Disclosed also nano-sized particles comprising the polysaccharide chemically cross-linked by aromatic dialdehydes. The nano-sized particles may further comprise lipids and surfactants. Intranasal delivery of the nano-sized particles enables delivery of biologically active agents into the brain. Topical and transdermal delivery of the nano-sized particles enables delivery of biologically active agents for treatment of systemic or dermatological disorders. Methods of manufacturing and uses of the compositions are also disclosed.
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