PROCESS FOR PREPARING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES

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United States of America Patent

APP PUB NO 20230002323A1
SERIAL NO

17589118

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Abstract

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Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

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Patent Owner(s)

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AKEBIA THERAPEUTICS INC245 FIRST STREET SUITE 1400 CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Copp, James Densmore Bargersville, US 16 194
Dixon, Craig Edward Brooklin, CA 8 114
Gorin, Boris Oakville, CA 39 232
Janusz, John Michael Oregonia, US 21 165
Lanthier, Christopher M Burlington, CA 9 112
Lu, Alan Quigbo Mississauga, CA 6 90
Oudenes, Jan Aurora, CA 25 229

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