METHOD FOR PREPARING CHONDROITIN SULFATE OLIGOSACCHARIDES WITH C5 PROTEIN TARGETING PROPERTY, AND APPLICATION THEREOF
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United States of America Patent
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Issued Date -
Dec 22, 2022
app pub date -
Feb 3, 2021
filing date -
Feb 3, 2021
priority date (Note) -
Published
status (Latency Note)
Importance
Abstract
A method for preparing chondroitin sulfate oligosaccharides with a C5 protein targeting property, and an application thereof, relating to the technical field of biomedicine. The method uses squid chondroitin sulfate as a raw material to prepare chondroitin sulfate oligosaccharides using enzymatic hydrolysis, using the method to screen the activity of various types of oligosaccharides in order to obtain the fragment with the best activity; the method is highly scientific and feasible. The method further uses the screened chondroitin sulfate disaccharides; the mechanism of chondroitin sulfate disaccharides in the treatment of osteoarthritis by regulating the complement system is explored and revealed by in vitro and in vivo experiments to finally provide a new way of treating osteoarthritis, thus having good practical application value.
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