METHOD FOR REDUCING THE EXPRESSION OF NKCC1 IN A SUBJECT

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United States of America Patent

APP PUB NO 20220380807A1
SERIAL NO

17861676

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Abstract

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The invention relates to an RNA interference (RNAi) strategy based on the use of artificial microRNA (amiR) to reduce NKCC1 expression. In particular, the invention relates to a vector that achieves neuron-specific expression of specific amiR against NKCC1 by using a human Synapsin promoter to drive transgene expression.

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Patent OwnerAddress
INST NAT SANTE RECH MED101 RUE DE TOLBIAC F-75013 PARIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cancedda, Laura Genova, IT 5 3
Contestabile, Andrea Genova, IT 3 0
Mingozzi, Federico Paris, FR 40 273
Ronzitti, Giuseppe Paris, FR 24 41

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