MODIFIED ORTHOPOXVIRUS VECTORS
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United States of America Patent
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Dec 1, 2022
app pub date -
Dec 20, 2019
filing date -
Dec 20, 2019
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The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.
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