COMPOSITION FOR CULTURING PERIPHERAL BLOOD MONOCYTE-DERIVED REGULATORY T CELL AND REGULATORY T CELL CULTURING METHOD USING SAME
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United States of America Patent
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Oct 20, 2022
app pub date -
Apr 7, 2020
filing date -
Sep 24, 2019
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Abstract
A composition for culturing peripheral blood monocyte-derived regulatory T cells includes at least one antibody selected from the group consisting of anti-CD2, anti-CD3, anti-CD7, anti-CD8, anti-CD28, anti-CD30L, anti-CD40, anti-CD70, anti-CD80, anti-CD83, and anti-CD86; at least one cytokine selected from the group consisting of interleukin-2, interleukin-4, interleukin-7, interleukin-12, interleukin-15, interleukin-34, and TGF-β; and superoxide dismutase. A regulatory T cell culturing method using this composition is also provided. The regulatory T cells according obtained by this method can be utilized for treatment of autoimmune diseases.
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