Macrocyclic compounds as proteasome inhibitors

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United States of America Patent

PATENT NO 11834515
APP PUB NO 20220324907A1
SERIAL NO

16755482

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Abstract

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The compounds of the present invention are represented by the following compounds having Formula I and Formula (I′): where the substituents R1, R2, R2′, R3, R4, R5, R′, R″, X, Y, and Z are as defined herein and where the substituents R1, R2, R3, R4, R5, R′, R″, X, Y, and Z are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.

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Patent Owner(s)

Patent OwnerAddress
CORNELL UNIVERSITYCENTER FOR TECHNOLOGY LICENSING (CTL) 395 PINE TREE ROAD SUITE 310 ITHACA NY 14850

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aso, Kazuyoshi Kanagawa, JP 26 225
Foley, Michael A New York, US 39 683
Ginn, John D New Milford, US 2 0
Hara, Ryoma Tokyo, JP 10 89
Imaeda, Toshihiro Kanagawa, JP 34 215
Kawasaki, Masanori Tokyo, JP 20 130
Kirkman, Laura New York, US 4 11
Lin, Gang Forest Hills, US 57 339
Morgan, Trevor Royston, GB 9 39
Nathan, Carl Larchmont, US 16 83
Okamoto, Rei Kanagawa, JP 12 24
Sato, Kenjiro Kanagawa, JP 14 77
Toita, Akinori Kanagawa, JP 8 8
Wong, Tzu-Tshin Acton, US 13 46
Yukawa, Takafumi Kanagawa, JP 15 30
Zhan, Wenhu Elmhurst, US 6 7

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