Method for preparation of tissue adhesive patches

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United States of America Patent

PATENT NO 11771799
APP PUB NO 20220323638A1
SERIAL NO

17850565

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Abstract

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A method of production of a tissue sealing patch is disclosed. The method comprises applying a vacuum to a heated work surface; applying a solution of a biocompatible polyurethane polymer to the work surface and spreading it over the work surface with a polymer blade; evaporating the solvent; heating the work surface above the softening temperature of the polymer; spreading powdered tissue sealant material over the polymer film; incorporating the tissue sealant material to a depth of 20-60 μm in the film by pressing on a release sheet placed over the powder and polymer film; removing the release sheet from the adhesive patch material; releasing the vacuum; cooling said work surface; and removing the adhesive patch material from said work surface. The biocompatible polymer preferably comprises PEG-caprolactone-lactic acid units connected by urethane linkages, the PEG having a molecular weight of 3000-3500 amu, and a CL:LA:PEG ratio of 34:2:1.

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Patent Owner(s)

Patent OwnerAddress
SEALANTIUM MEDICAL LTD11 AMAL STREET AFEK INDUSTRIAL PARK 4809239 ROSH HA'AYIN ISRAEL

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cohen, Eran Hod Hasharon, IL 57 321
Laub, Orgad Tel Aviv, IL 15 91
Schwartz, Yotam Petah Tiqwa, IL 5 3

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