EXPANDABLE LIVER ORGANOIDS, MEDIA COMPOSITION FOR DIFFERENTIATION THEREOF, AND METHOD FOR PRODUCING LIVER ORGANOIDS USING THE SAME

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United States of America

SERIAL NO

17686669

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Abstract

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The present invention relates to expandable liver organoids, a medium composition for differentiation thereof, and a method for producing liver organoids using the same, and the liver organoids according to the present invention exhibit the characteristics of more mature hepatocytes than 2D differentiated hepatocytes, can be subcultured up to 90 times or more, and exhibit the expandability for maintaining the characteristics of mature hepatocytes even after multiple subcultures, and thus can be usefully utilized for predicting toxicity, regeneration, and inflammatory response, drug screening, and modeling of diseases such as hepatic steatosis.

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Patent Owner(s)

Patent OwnerAddress
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY125 GWAHAK-RO YUSEONG-GU DAEJEON 34141

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHO, Hyun-Soo Daejeon, KR 4 1
CHUNG, Kyung-Sook Daejeon, KR 13 15
JUNG, Cho-Rok Daejeon, KR 9 7
KIM, Dae Soo Daejeon, KR 32 30
MUN, Seonju Daejeon, KR 2 0
RYU, Jae Sung Daejeon, KR 3 0
SON, Myung Jin Daejeon, KR 6 3

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