Bicyclic peptide ligands specific for TREM2

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United States of America Patent

PATENT NO 11904020
APP PUB NO 20220296726A1
SERIAL NO

17698185

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Abstract

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The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.

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Patent Owner(s)

Patent OwnerAddress
CHANCELLOR MASTER AND SCHOLARS OF THE UNIVERSITY OF OXFORDUNIVERSITY OFFICES WELLINGTON SQUARE OXFORD OX1 2JD

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brennan, Paul Cambridge, GB 16 63
Brown, Amy Cambridge, GB 5 10
Chen, Liuhong Cambridge, GB 40 136
Davis, John Cambridge, GB 155 4709
Demydchuk, Yuliya Cambridge, GB 3 0
Di, Rienzo Donatella Cambridge, GB 1 0
Gowans, Ellen Cambridge, GB 3 0
McCrory, Rama Cambridge, GB 1 0
Mead, Emma Cambridge, GB 1 0
Murphy, Emma Cambridge, GB 4 0
Rigby, Mike Cambridge, GB 2 0
Skynner, Michael Cambridge, GB 22 79
Smith, Tom Cambridge, GB 21 159
Stanway, Steven Cambridge, GB 4 0

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