METHODS AND COMPOSITIONS FOR STABILIZING NUCLEIC ACID-NUCLEOTIDE-POLYMERASE COMPLEXES

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United States of America Patent

APP PUB NO 20220290216A1
SERIAL NO

17568077

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods, compositions, kits and apparatuses that include a fluid, the fluid containing a ternary complex and Li+, wherein the ternary complex includes a primed template nucleic acid, a polymerase, and a nucleotide cognate for the next correct base for the primed template nucleic acid molecule. As an alternative or addition to Li+, the fluid can contain betaine or a metal ion that inhibits polymerase catalysis such as Ca2+. In addition to Li+, the fluid can contain polyethylenimine (PEI) with or without betaine.

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Patent Owner(s)

Patent OwnerAddress
PACIFIC BIOSCIENCES OF CALIFORNIA INC1305 O'BRIEN DRIVE MENLO PARK CA 94025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BLOCK, Fabian San Diego, US 8 23
IYIDOGAN, Pinar San Diego, US 19 128
LIU, Ying Lin San Diego, US 3 21
MIDDLETON, Morassa Mohseni San Diego, US 5 29
OLIPHANT, Arnold Morgan Hill, US 102 3734
ROHRMAN, Brittany A La Jolla, US 7 31
SCHMIDT, Michael James San Diego, US 17 183
WALLEN, Mark C San Diego, US 7 44

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