2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS
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United States of America Patent
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Issued Date -
Sep 15, 2022
app pub date -
May 24, 2022
filing date -
Nov 2, 2018
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Abstract
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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