Efficient delivery of therapeutic molecules to cells of the inner ear

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United States of America Patent

PATENT NO 12043653
APP PUB NO 20220281941A1
SERIAL NO

17750530

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Abstract

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Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

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Patent Owner(s)

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PRESIDENT AND FELLOWS OF HARVARD COLLEGE17 QUINCY STREET CAMBRIDGE MA 02138

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Zheng-Yi Chestnut Hill, US 20 62
Li, Margie Cambridge, US 5 1
Liu, David R Lexington, US 236 9909
Thompson, David B Cambridge, US 30 1795
Zuris, John Cambridge, US 5 6

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