PRODUCTION METHOD FOR LIPID PARTICLES IN LIQUID AND METHOD FOR CULTURING MICROORGANISMS
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United States of America Patent
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Aug 25, 2022
app pub date -
May 11, 2022
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Nov 25, 2019
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Abstract
A method for producing lipid particles, including: injecting molten lipids directly into a liquid at a temperature lower than a melting point of the lipids through a liquid supply port of a two-fluid nozzle while injecting a gas directly into the liquid through a gas supply port of the two-fluid nozzle, so that the molten lipids are dispersed and atomized into particles in the liquid due to the gas and the particles are solidified to form lipid particles. The lipids have a water solubility of 10 g/L or less at 25° C. and are solid at 25° C. The two-fluid nozzle is heated to a temperature at least 10° C. higher than the melting point of the lipids. A ratio D50/Nd of a volume median diameter D50 of the lipid particles to an orifice diameter Nd of the liquid supply port of the two-fluid nozzle is 0.0017 or more and 0.17 or less.
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