METHODS AND COMPOSITIONS FOR GENERATING NITRIC OXIDE AND USES THEREOF TO DELIVER NITRIC OXIDE VIA THE RESPIRATORY TRACT
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United States of America Patent
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Issued Date -
Aug 18, 2022
app pub date -
Jun 2, 2020
filing date -
Jun 4, 2019
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Abstract
A combination, kit or composition is disclosed, comprising: (i) one or more nitrite salt; (ii) a proton source comprising one or more acid selected from organic carboxylic acids and organic non-carboxylic reducing acids; and (iii) one or more organic polyol. On reaction of the one or more nitrite salt with the proton source in the presence of the one or more organic polyol, the combination, kit or composition provides reaction products which include nitric oxide, optionally other oxides of nitrogen and/or optionally precursors thereof and which are useful in the treatment of various disorders via delivery of the combination or composition or the nitric oxide, optionally other oxides of nitrogen and/or optionally precursors thereof to a subject via the respiratory tract.
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