AMORPHOUS SOLID FORM OF COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND SODIUM CATIONS

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United States of America Patent

APP PUB NO 20220257551A1
SERIAL NO

17738565

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Abstract

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An amorphous solid form of a compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and sodium cations is provided. This is compound is useful for the treatment of hypertension and/or heart failure.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS PHARMACEUTICALS CORPORATIONONE HEALTH PLAZA EAST HANOVER NJ 07936

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BLACKLOCK, Thomas J East Hanover, US 24 179
FENG, Lili Pine Brook, US 31 104
GIRGIS, Michael J Montville, US 21 77
GODTFREDSEN, Sven Erik Chatham, US 17 69
HU, Bin Green Brook, US 275 1156
KARPINSKI, Piotr Henryk Lincoln Park, US 10 34
LIU, Yugang Warren, US 44 127
PRASHAD, Mahavir Montville, US 44 236
SUTTON, Paul Allen Getzville, US 36 203

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