METHODS OF TREATING INFECTIONS BY BLOCKING PATHOGEN MIMICS OF CD47
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United States of America Patent
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Jul 28, 2022
app pub date -
Jun 16, 2020
filing date -
Jun 17, 2019
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Abstract
Methods are provided for treating a subject for an infection by a pathogen expressing a CD47-like mimic protein on its surface. In particular, the methods comprise administering an agent that reduces the binding of the CD47 mimic protein on the pathogen to SIRPα on a phagocytic cell, wherein the agent is administered at an effective dose for increasing phagocytosis of the pathogen
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