SHERLOCK ASSAYS FOR TICK-BORNE DISEASES
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United States of America Patent
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Jul 14, 2022
app pub date -
Mar 13, 2020
filing date -
Mar 14, 2019
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Provided herein is a nucleic acid detection system comprising a detection CRISPR system having an effector protein and one or more guide RNAs each designed to bind to corresponding target molecules that are diagnostic for a tick-borne disease state; and an RNA-based masking construct. In some embodiments, the detection system of may comprise i) two or more CRISPR systems, each CRISPR system comprising an effector protein and a guide RNA designed to bind to a corresponding target molecule that is diagnostic for a tick-borne disease state; and ii) a set of detection constructs, each detection construct comprising a cutting motif sequence that is preferentially cut by one of the activated CRISPR effector proteins. Exemplary tick-borne detectable microbes include Babesia micron, Anaplasma phagocytophilum, and Borrelia miyamotoi.
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