ARRAY-BASED TRANSLOCATION AND REARRANGEMENT ASSAYS

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20220205041A1
SERIAL NO

17014939

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods for detecting genomic rearrangements are provided. In one embodiment, methods are provided for the use of paired end tags from restriction fragments to detect genomic rearrangements. Sequences from the ends of the fragments are brought together to form ditags and the ditags are detected. Combinations of ditags are detected by an on-chip sequencing strategy that is described herein, using inosine for de novo sequencing of short segments of DNA. In another aspect, translocations are identified by using target specific capture and analysis of the captured products on a tiling array.

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Patent Owner(s)

Patent OwnerAddress
AFFYMETRIX INC3420 CENTRAL EXPRESSWAY SANTA CLARA CA 95051

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fu, Glenn K Dublin, US 56 4444
Jones, Keith W Sunnyvale, US 45 1499
Shapero, Michael H Campbell, US 39 1571
Sparks, Andrew Los Gatos, US 72 2199

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