METHODS OF TREATMENT FOR BACTERIAL INFECTIONS
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United States of America
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Jun 30, 2022
app pub date -
Dec 2, 2021
filing date -
Dec 2, 2021
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Abstract
This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.
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