METHOD FOR PRODUCING PEPTIDE COMPOUND
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United States of America Patent
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Issued Date -
May 19, 2022
app pub date -
Mar 16, 2020
filing date -
Mar 16, 2020
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Abstract
The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).
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