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Abstract

The invention provides a method for the formation of a tissue-targeting thorium complex, said method comprising;

a) forming an octadentate chelator comprising four hydroxypyridinone (HOPO) moieties, substituted in the N-position with a methyl group, and a coupling moiety terminating in a carboxylic acid group;b) coupling said octadentate chelator to at least one tissue-targeting moiety targeting HER2; andc) contacting said tissue-targeting chelator with an aqueous solution comprising an ion of at least one alpha-emitting thorium isotope.A method of treatment of a neoplastic or hyperplastic disease comprising administration of such a tissue-targeting thorium complex, as well as the complex and corresponding pharmaceutical formulations are also provided

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First Claim